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Spirulan, a calcium-rich internal polysaccharide of Spirulina, is potentially responsible for its antiviral effect through inhibiting the entry of several viruses into the host cells, boosting the production of nitric oxide in macrophages, and stimulating the generation of cytokines

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Studying two cohorts of CFS ( n = 10) and GWS patients ( n = 10), one pooled and the other looking at individual cases, Baraniuk found very similar CSF proteome differences relative to a healthy control group ( n = 10) (Baraniuk et al., 2015)