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62 Thus, consistent with the very low levels of LPO, 55,62 lysosomal ferrous iron translocated into mitochondria promotes MPTP opening and APAP-induced cell death through facilitation of protein nitration, rather than generation of LPO under normal conditions

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Plasma malondialdehyde (oxidative stress marker) increases 28% in patients losing more than 1% body weight weekly without antioxidant support