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Interestingly, B lymphocytes can easily penetrate the synovium and damage the cartilages during the occurrence of arthritis

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Le Cu2+ libre est toxique (réactions de Fenton, radicaux hydroxyle), mais le complexe GHK-Cu est stable, diffusible et délivre le cuivre de manière ciblée vers les métalloenzymes dépendantes : lysyl oxydase (réticulation collagène/élastine), superoxyde dismutase Cu/Zn (SOD1, défense antioxydante), tyrosinase (mélanogenèse contrôlée), dopamine-beta-hydroxylase